TUBA3D

Across TCGA cell cohorts, TUBA3D RNA expression is significantly associated with the go_rna of many other GO terms, with 4,055 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TUBA3D-associated GO terms across cancer lineages are Negative regulation of mRNA splicing, via spliceosome, Negative regulation of mRNA processing, and Pre-mRNA catabolic process. Each is linked with TUBA3D in more than 15 cancer types. Because this analysis shows association rather than direction, both TUBA3D-to-partner and partner-to-TUBA3D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of mRNA splicing, via spliceosome grouped by TUBA3D-low versus TUBA3D-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBA3D→partner) and Y-score (partner→TUBA3D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Negative regulation of mRNA splicing, via spliceosome →	+0.113	+0.392	<.001	<.001	3	16
SOFT_TISSUE	Negative regulation of mRNA processing →	+0.108	+0.374	<.001	<.001	3	16
BONE	Pre-mRNA catabolic process →	+0.221	+0.463	<.001	<.001	3	15
SOFT_TISSUE	RNA export from nucleus →	+0.123	+0.367	<.001	<.001	3	15
BONE	Signal transduction in response to DNA damage →	+0.078	+0.469	<.001	<.001	3	15
BREAST	Positive regulation of DNA recombination →	+0.076	+0.407	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,055 associations by consensus.

Negative regulation of mRNA splicing, via spliceosome by TUBA3D expression — SOFT_TISSUE

Explore this box plot interactively →