TUBA1A

Across TCGA patient cohorts, TUBA1A mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TUBA1A-associated genes across cancer lineages are FOXO3a_pS318_S321, GAPDH, and GSK-3_pS9. Each is linked with TUBA1A in more than 1 cancer types. Because this analysis shows association rather than direction, both TUBA1A-to-partner and partner-to-TUBA1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by TUBA1A-low versus TUBA1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBA1A→partner) and Y-score (partner→TUBA1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.160	-2.575	.002	.010	3	1
UCEC	GAPDH →	+0.618	+3.169	.006	.018	3	1
UCEC	GSK-3_pS9 →	-0.540	-2.000	.001	.029	3	1
UCEC	MEK1 →	+0.349	+2.321	.024	.034	3	1
UCEC	MSH2 →	-0.447	-3.449	<.001	.005	3	1
UCEC	mTOR_pS2448 →	-0.173	-1.700	.006	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

FOXO3a_pS318_S321 by TUBA1A expression — UCEC

Explore this box plot interactively →