TTYH3

Across TCGA patient cohorts, TTYH3 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTYH3-associated genes across cancer lineages are Caspase-7-cleavedD198, 14-3-3_beta, and EGFR_pY1068. Each is linked with TTYH3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTYH3-to-partner and partner-to-TTYH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TTYH3-low versus TTYH3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTYH3→partner) and Y-score (partner→TTYH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.563	+3.169	.015	.018	3	2
UCEC	14-3-3_beta →	-0.111	-3.432	.004	.005	3	1
UCEC	EGFR_pY1068 →	-0.264	-2.000	.007	.010	3	1
UCEC	eIF4E →	+0.239	+2.700	.003	.006	2	2
UCEC	eIF4G →	+0.252	+2.321	.038	.033	3	1
UCEC	ERK2 →	+0.252	+3.459	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Caspase-7-cleavedD198 by TTYH3 expression — UCEC

Explore this box plot interactively →