TTYH3

Across TCGA cell cohorts, TTYH3 mutation is significantly associated with the RNA expression of many other genes, with 526 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TTYH3-associated genes across cancer lineages are CCDC134, USP42, and FEM1A. Each is linked with TTYH3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTYH3-to-partner and partner-to-TTYH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC134 grouped by TTYH3-low versus TTYH3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTYH3→partner) and Y-score (partner→TTYH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CCDC134 →	+0.734	+3.212	.004	.006	3	2
BLOOD_Leukemia	USP42 →	+0.587	+3.199	.004	.007	3	2
BLOOD_Leukemia	FEM1A →	+0.517	+3.199	.003	.007	3	2
BLOOD_Leukemia	GATAD2B →	+0.679	+3.199	.001	.007	3	2
BLOOD_Leukemia	CYP4V2 →	+1.132	+3.199	.002	.007	3	2
BLOOD_Leukemia	CCNF →	+0.680	+3.199	.007	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 526 associations by consensus.

CCDC134 by TTYH3 expression — LARGE_INTESTINE

Explore this box plot interactively →