TTYH2

Across TCGA patient cohorts, TTYH2 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTYH2-associated genes across cancer lineages are Notch1, ASNS, and ATM. Each is linked with TTYH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTYH2-to-partner and partner-to-TTYH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by TTYH2-low versus TTYH2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTYH2→partner) and Y-score (partner→TTYH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.209	+2.584	<.001	.001	3	2
UCEC	ASNS →	+0.342	+2.222	.013	.010	3	2
UCEC	ATM →	-0.649	-2.087	<.001	.005	3	2
UCEC	Caspase-8 →	-0.220	-3.558	.022	.002	3	2
UCEC	C-Raf →	+0.138	+2.000	.012	.030	3	2
UCEC	FoxM1 →	+0.256	+2.087	.009	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Notch1 by TTYH2 expression — UCEC

Explore this box plot interactively →