TTYH2

Across TCGA cell cohorts, TTYH2 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. CNS shows the largest number of these associations.

The most reproducible TTYH2-associated genes across cancer lineages are IQCF5, OR5G3, and FAM236A. Each is linked with TTYH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTYH2-to-partner and partner-to-TTYH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF5 grouped by TTYH2-low versus TTYH2-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTYH2→partner) and Y-score (partner→TTYH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	IQCF5 →	+0.056	+5.357	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	OR5G3 →	+0.021	+4.736	.009	.009	3	1
UPPER_AERODIGESTIVE_TRACT	FAM236A →	+0.120	+5.357	<.001	.003	3	1
CNS	OR2T10 →	+0.009	+4.169	<.001	.008	3	1
CNS	AQP12B →	+0.080	+4.447	.001	.001	3	1
CNS	OR2J1 →	+0.010	+4.772	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

IQCF5 by TTYH2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →