TTYH1

Across TCGA patient cohorts, TTYH1 mutation is significantly associated with the RNA expression of many other genes, with 1,496 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTYH1-associated genes across cancer lineages are WDR76, TXNL4B, and SUMO2P5. Each is linked with TTYH1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TTYH1-to-partner and partner-to-TTYH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WDR76 grouped by TTYH1-low versus TTYH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTYH1→partner) and Y-score (partner→TTYH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	WDR76 →	+0.843	+2.684	<.001	<.001	3	3
UCEC	TXNL4B →	+0.482	+3.470	.001	.002	3	3
LUSC	SUMO2P5 →	+0.210	+5.337	<.001	.006	3	3
UCEC	COX15 →	+0.395	+2.329	.004	.003	3	2
UCEC	SKA1 →	+0.647	+1.776	.001	.008	3	2
UCEC	MPPE1 →	+0.452	+1.914	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,496 associations by consensus.

WDR76 by TTYH1 expression — UCEC

Explore this box plot interactively →