TTYH1

Across TCGA patient cohorts, TTYH1 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTYH1-associated genes across cancer lineages are ASNS, Shc_pY317, and Bak. Each is linked with TTYH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTYH1-to-partner and partner-to-TTYH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by TTYH1-low versus TTYH1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTYH1→partner) and Y-score (partner→TTYH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.568	+2.815	.009	.036	3	2
UCEC	Shc_pY317 →	-0.142	-2.115	.031	.019	3	2
UCEC	Bak →	+0.269	+2.321	.014	.033	3	2
UCEC	Caspase-7-cleavedD198 →	+0.573	+3.189	.027	.010	3	2
COAD	FASN →	+0.434	+2.815	.043	.036	3	1
COAD	14-3-3_epsilon →	+0.198	+2.849	.004	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

ASNS by TTYH1 expression — COAD

Explore this box plot interactively →