TTYH1

Across TCGA cell cohorts, TTYH1 mutation is significantly associated with the mutation status of many other genes, with 3,618 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TTYH1-associated genes across cancer lineages are DHX37, TMPRSS9, and P2RY8. Each is linked with TTYH1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TTYH1-to-partner and partner-to-TTYH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DHX37 grouped by TTYH1-low versus TTYH1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTYH1→partner) and Y-score (partner→TTYH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DHX37 →	+5.772	+5.772	.002	.002	1	3
LARGE_INTESTINE	TMPRSS9 →	+2.321	+2.643	.004	.004	1	3
LARGE_INTESTINE	P2RY8 →	+3.222	+2.893	.003	.003	1	3
LARGE_INTESTINE	NDOR1 →	+3.222	+2.893	.003	.003	1	3
BLOOD_Leukemia	COL5A2 →	+3.338	+4.083	.003	.003	1	3
LARGE_INTESTINE	ACD →	+2.129	+2.504	.007	.007	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,618 associations by consensus.

DHX37 by TTYH1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →