TTPAL

Across TCGA pan-cancer cohorts, TTPAL Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TTPAL data layer compared with 27 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher TTPAL Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TTPAL expression acts as an unfavorable survival marker.

ESCA, LUSC, and UCEC are the cancer types where TTPAL Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	All	0.198	0.872	.003	18	view →
LUSC	DFS	Median	II,III,IV	0.199	0.748	.006	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	DFS	Median	III,IV	0.053	0.648	<.001	6	view →
COAD	DFS	Median	All	0.118	0.556	.040	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TTPAL–ESCA (OS)

Open the ESCA breakdown →