TTPAL

Across TCGA pan-cancer cohorts, TTPAL mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TTPAL data layer compared with 27 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TTPAL mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TTPAL expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

PDAC, LSCC, and CCRCC are the cancer types where TTPAL mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	III,IV	0.173	0.748	.011	26	view →
LSCC	OS	Tertile	III,IV	0.572	0.918	.035	4	view →
CCRCC	DFS	Quartile	II,III,IV	1.000	0.799	.038	1	view →
HNSC	DFS	Median	III,IV	1.000	0.939	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TTPAL–PDAC (DFS)

Open the PDAC breakdown →