TTPAL

Across TCGA cell cohorts, TTPAL mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TTPAL-associated genes across cancer lineages are BPIFB6, SIGLECL1, and C6. Each is linked with TTPAL in more than 1 cancer types. Because this analysis shows association rather than direction, both TTPAL-to-partner and partner-to-TTPAL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BPIFB6 grouped by TTPAL-low versus TTPAL-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTPAL→partner) and Y-score (partner→TTPAL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BPIFB6 →	+0.016	+4.022	<.001	.006	3	2
BREAST	SIGLECL1 →	+0.020	+4.781	<.001	.003	3	1
BLOOD_Leukemia	C6 →	+0.201	+4.922	<.001	.009	3	1
LARGE_INTESTINE	SLC22A8 →	+0.023	+3.196	.002	.007	3	1
LARGE_INTESTINE	UTF1 →	+0.020	+3.632	<.001	.003	3	1
LARGE_INTESTINE	REG1B →	+1.756	+3.196	.007	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

BPIFB6 by TTPAL expression — LARGE_INTESTINE

Explore this box plot interactively →