TTN

Across TCGA pan-cancer cohorts, TTN Mutation is linked to patient survival in 20 of 34 cancer types, making it a survival-associated TTN data layer compared with 21 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in thyroid carcinoma (THCA), where higher TTN Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TTN expression acts as an unfavorable survival marker, although some lineages such as LUSC and KIRC show a favorable association.

THCA, LUSC, and KIRC are the cancer types where TTN Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	DFS	Median	All	0.526	0.841	<.001	24	view →
LUSC	DFS	Median	All	0.799	0.681	<.001	19	view →
KIRC	DFS	Median	II,III,IV	0.986	0.687	.012	14	view →
CESC	DFS	Median	III,IV	0.642	0.238	.015	10	view →
PCPG	OS	Median	All	0.805	0.975	.011	9	view →
DLBC	OS	Median	All	0.473	0.945	.006	9	view →
KICH	DFS	Median	All	0.299	0.859	.003	7	view →
SKCM	OS	Median	II,III,IV	0.872	0.743	.003	7	view →
LAML	DFS	Median	All	0.082	0.582	.004	6	view →
PAAD	DFS	Median	All	0.257	0.526	.020	6	view →
LGG	DFS	Median	All	0.223	0.479	.003	6	view →
STAD	DFS	Median	II,III,IV	0.655	0.392	.013	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

TTN–THCA (DFS)

Open the THCA breakdown →