TTN-AS1

Across TCGA pan-cancer cohorts, TTN-AS1 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated TTN-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher TTN-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TTN-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCS and THYM show a favorable association.

KIRC, ACC, and UVM are the cancer types where TTN-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	IV	0.352	0.624	.003	65	view →
ACC	DFS	Quartile	III,IV	0.061	0.477	.006	55	view →
UVM	DFS	Quartile	III,IV	0.276	0.914	.004	26	view →
UCS	DFS	Median	IV	0.952	0.473	.018	24	view →
THYM	DFS	Median	All	0.967	0.657	.005	18	view →
LGG	DFS	Tertile	All	0.654	0.795	.002	13	view →
COAD	OS	Quartile	IV	0.417	0.866	.025	9	view →
LUSC	DFS	Median	II,III,IV	0.633	0.868	.007	8	view →
LAML	DFS	Quartile	All	0.497	0.232	.019	6	view →
READ	DFS	Quartile	II,III,IV	0.646	0.354	.039	5	view →
LIHC	DFS	Tertile	II,III,IV	0.310	0.453	.023	4	view →
ESCA	DFS	Quartile	II,III,IV	1.000	0.367	.046	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

TTN-AS1–KIRC (DFS)

Open the KIRC breakdown →