TTLL7

Across TCGA cell cohorts, TTLL7 mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TTLL7-associated genes across cancer lineages are OR2A2, SIX6, and TEX44. Each is linked with TTLL7 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTLL7-to-partner and partner-to-TTLL7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2A2 grouped by TTLL7-low versus TTLL7-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTLL7→partner) and Y-score (partner→TTLL7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OR2A2 →	+0.035	+4.087	<.001	.009	3	2
BLOOD_Leukemia	SIX6 →	+1.434	+3.769	<.001	.008	3	2
OESOPHAGUS	TEX44 →	+0.050	+3.714	<.001	.002	3	1
OESOPHAGUS	HTR3D →	+0.023	+3.273	<.001	.004	3	1
OESOPHAGUS	TBC1D3G →	+0.706	+3.643	.002	.003	3	1
URINARY_TRACT	TMIGD3 →	+0.076	+4.584	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

OR2A2 by TTLL7 expression — URINARY_TRACT

Explore this box plot interactively →