TTLL6

Across TCGA patient cohorts, TTLL6 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTLL6-associated genes across cancer lineages are Smad1, INPP4B, and Paxillin. Each is linked with TTLL6 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTLL6-to-partner and partner-to-TTLL6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Smad1 grouped by TTLL6-low versus TTLL6-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTLL6→partner) and Y-score (partner→TTLL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Smad1 →	-0.171	-3.169	.029	.019	3	2
UCEC	INPP4B →	-0.333	-3.321	<.001	<.001	3	2
UCEC	Paxillin →	+0.165	+1.598	.037	.040	3	2
UCEC	Shc_pY317 →	-0.184	-2.137	<.001	<.001	3	2
UCEC	VHL →	-0.787	-1.415	<.001	.008	3	2
UCEC	ATM →	-0.544	-1.947	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Smad1 by TTLL6 expression — SKCM

Explore this box plot interactively →