TTLL6

Across TCGA cell cohorts, TTLL6 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TTLL6-associated genes across cancer lineages are SOX14, C11orf53, and OR2T10. Each is linked with TTLL6 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTLL6-to-partner and partner-to-TTLL6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SOX14 grouped by TTLL6-low versus TTLL6-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTLL6→partner) and Y-score (partner→TTLL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	SOX14 →	+0.006	+5.000	<.001	.005	3	2
KIDNEY	C11orf53 →	+0.033	+5.000	<.001	.005	3	1
KIDNEY	OR2T10 →	+0.320	+5.000	<.001	.005	3	1
KIDNEY	GPR33 →	+0.023	+5.000	<.001	.005	3	1
LUNG_NSCLC_LUAD	CLEC4D →	+0.040	+4.415	.003	<.001	3	1
LUNG_NSCLC_LUAD	TDRD1 →	+1.114	+3.736	.009	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

SOX14 by TTLL6 expression — KIDNEY

Explore this box plot interactively →