TTLL5

Across TCGA pan-cancer cohorts, TTLL5 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated TTLL5 data layer compared with 22 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher TTLL5 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TTLL5 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

SCLC, UCS, and UCEC are the cancer types where TTLL5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	DFS	Median	All	0.192	0.580	.011	15	view →
UCS	OS	Median	III,IV	0.102	0.591	<.001	12	view →
UCEC	DFS	Median	All	0.762	0.634	.017	12	view →
SKCM	OS	Median	All	0.256	0.784	<.001	12	view →
PRAD	DFS	Median	All	0.617	0.886	.043	6	view →
ACC	DFS	Median	II,III,IV	0.057	0.581	.003	6	view →
ESCA	OS	Median	II,III,IV	0.295	0.707	.005	6	view →
BLCA	DFS	Median	All	1.000	0.506	.032	6	view →
STAD	DFS	Median	III,IV	0.900	0.461	.024	4	view →
COAD	OS	Median	All	0.694	0.872	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

TTLL5–SCLC (DFS)

Open the SCLC breakdown →