TTLL5

Across TCGA patient cohorts, TTLL5 mutation is significantly associated with the RNA expression of many other genes, with 3,717 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTLL5-associated genes across cancer lineages are NPB, NOP10, and TEDC1. Each is linked with TTLL5 in more than 3 cancer types. Because this analysis shows association rather than direction, both TTLL5-to-partner and partner-to-TTLL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPB grouped by TTLL5-low versus TTLL5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTLL5→partner) and Y-score (partner→TTLL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	NPB →	+0.074	+2.847	.001	.002	3	4
UCEC	NOP10 →	+0.417	+2.566	<.001	<.001	3	3
SKCM	TEDC1 →	+0.536	+3.488	.003	.002	2	4
UCEC	FANCA →	+0.632	+3.136	<.001	<.001	3	3
UCEC	ZNF511 →	+0.281	+2.021	.002	.005	3	3
UCEC	VDAC1 →	+0.379	+2.069	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,717 associations by consensus.

NPB by TTLL5 expression — SKCM

Explore this box plot interactively →