TTLL5

Across TCGA patient cohorts, TTLL5 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTLL5-associated genes across cancer lineages are c-Kit, Di-Ras3, and ERK2. Each is linked with TTLL5 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTLL5-to-partner and partner-to-TTLL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Kit grouped by TTLL5-low versus TTLL5-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTLL5→partner) and Y-score (partner→TTLL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	c-Kit →	-0.275	-2.459	.045	.019	3	2
COAD	Di-Ras3 →	-0.211	-2.991	.037	.036	3	2
UCEC	ERK2 →	+0.185	+1.321	.001	.012	3	2
UCEC	IGFBP2 →	-0.632	-2.415	.001	.002	3	2
UCEC	MEK1 →	+0.389	+2.999	<.001	<.001	3	2
UCEC	MSH2 →	-0.223	-2.143	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

c-Kit by TTLL5 expression — STAD

Explore this box plot interactively →