TTLL5

Across TCGA cell cohorts, TTLL5 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,367 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TTLL5-associated GO terms across cancer lineages are Negative regulation of cell cycle process, Cell cycle checkpoint signaling, and mRNA alternative polyadenylation. Each is linked with TTLL5 in more than 17 cancer types. Because this analysis shows association rather than direction, both TTLL5-to-partner and partner-to-TTLL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cell cycle process grouped by TTLL5-low versus TTLL5-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TTLL5→partner) and Y-score (partner→TTLL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of cell cycle process →	+0.054	+0.778	<.001	<.001	3	18
SOFT_TISSUE	Cell cycle checkpoint signaling →	+0.080	+0.767	<.001	.001	3	18
KIDNEY	mRNA alternative polyadenylation →	+0.094	+1.098	.002	.002	3	17
PANCREAS	Replication fork processing →	+0.112	+0.889	<.001	<.001	3	17
PANCREAS	DNA recombination →	+0.072	+0.715	.002	.005	3	17
SOFT_TISSUE	Mitotic G2 DNA damage checkpoint signaling →	+0.092	+0.738	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,367 associations by consensus.

Negative regulation of cell cycle process by TTLL5 expression — BREAST

Explore this box plot interactively →