TTLL5

Across TCGA cell cohorts, TTLL5 mutation is significantly associated with the RNA expression of many other genes, with 312 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TTLL5-associated genes across cancer lineages are OR5AU1, ZNF48, and LIPM. Each is linked with TTLL5 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTLL5-to-partner and partner-to-TTLL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5AU1 grouped by TTLL5-low versus TTLL5-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTLL5→partner) and Y-score (partner→TTLL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR5AU1 →	+0.021	+3.149	<.001	<.001	3	2
LARGE_INTESTINE	ZNF48 →	+0.584	+2.364	<.001	<.001	3	2
CNS	LIPM →	+0.038	+4.643	.008	.003	3	2
LARGE_INTESTINE	GRHL2 →	+0.918	+1.850	.009	.006	3	2
PANCREAS	GAGE12E →	+0.046	+5.614	<.001	.002	3	1
LUNG_NSCLC_LUAD	SLA2 →	+0.115	+3.352	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 312 associations by consensus.

OR5AU1 by TTLL5 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →