TTLL4

Across TCGA cell cohorts, TTLL4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,959 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TTLL4-associated GO terms across cancer lineages are DNA-templated DNA replication maintenance of fidelity, Telomere organization, and Nuclear pore complex assembly. Each is linked with TTLL4 in more than 15 cancer types. Because this analysis shows association rather than direction, both TTLL4-to-partner and partner-to-TTLL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated DNA replication maintenance of fidelity grouped by TTLL4-low versus TTLL4-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TTLL4→partner) and Y-score (partner→TTLL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	DNA-templated DNA replication maintenance of fidelity →	+0.101	+1.230	.002	<.001	3	16
BONE	Telomere organization →	+0.073	+1.060	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Nuclear pore complex assembly →	+0.127	+0.650	.001	.003	3	15
BONE	DNA replication →	+0.118	+1.042	<.001	.001	3	15
BONE	Telomere maintenance →	+0.084	+1.173	<.001	<.001	3	15
SOFT_TISSUE	Double-strand break repair via homologous recombination →	+0.067	+0.894	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,959 associations by consensus.

DNA-templated DNA replication maintenance of fidelity by TTLL4 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →