TTLL4

Across TCGA cell cohorts, TTLL4 mutation is significantly associated with the RNA expression of many other genes, with 443 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TTLL4-associated genes across cancer lineages are OBP2A, CFHR5, and IDI2. Each is linked with TTLL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTLL4-to-partner and partner-to-TTLL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OBP2A grouped by TTLL4-low versus TTLL4-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTLL4→partner) and Y-score (partner→TTLL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OBP2A →	+0.716	+4.369	<.001	.008	3	1
SOFT_TISSUE	CFHR5 →	+0.069	+4.882	<.001	.001	3	1
SOFT_TISSUE	IDI2 →	+1.644	+4.417	<.001	.004	3	1
SOFT_TISSUE	MS4A6E →	+0.317	+5.515	<.001	<.001	3	1
SOFT_TISSUE	SPACA5B →	+0.681	+4.369	<.001	.008	3	1
SOFT_TISSUE	OR2T29 →	+0.657	+4.369	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 443 associations by consensus.

OBP2A by TTLL4 expression — SOFT_TISSUE

Explore this box plot interactively →