Across TCGA pan-cancer cohorts, TTLL3 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TTLL3 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher TTLL3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TTLL3 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUSC, UCEC, and ESCA are the cancer types where TTLL3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	II,III,IV	0.140	0.743	.001	24	view →
UCEC	DFS	Median	All	0.972	0.606	.003	12	view →
ESCA	OS	Median	II,III,IV	0.216	0.702	.014	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: TTLL3 tumor-vs-normal RNA expression · all TTLL3 data types