Across TCGA patient cohorts, TTLL3 mutation is significantly associated with the RNA expression of many other genes, with 2,438 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTLL3-associated genes across cancer lineages are TLCD3A, TIMM21, and NANS. Each is linked with TTLL3 in more than 2 cancer types. Because this analysis shows association rather than direction, both TTLL3-to-partner and partner-to-TTLL3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTLL3→partner) and Y-score (partner→TTLL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TLCD3A →	+0.430	+2.010	.006	.005	3	3
UCEC	TIMM21 →	+0.414	+1.868	<.001	<.001	3	3
UCEC	NANS →	+0.394	+2.130	.001	.002	3	3
COAD	CORT →	+0.445	+3.551	<.001	.002	3	3
UCEC	TPI1 →	+0.359	+2.777	.006	<.001	3	3
UCEC	CDAN1 →	+0.318	+1.740	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,438 associations by consensus.

Exploration

TTLL3 survival (RNA) · tumor vs normal (RNA) · all TTLL3 data types