TTLL3

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, TTLL3 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTLL3-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and JNK2. Each is linked with TTLL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTLL3-to-partner and partner-to-TTLL3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTLL3→partner) and Y-score (partner→TTLL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
COADEGFR_pY1068 →-0.396-3.000.010.03432
UCECeIF4E →+0.208+2.415.002.00332
UCECJNK2 →+0.276+2.321<.001<.00132
UCECSrc_pY527 →-0.290-1.797.037.02532
COADCaspase-7-cleavedD198 →+1.237+2.824<.001.03432
UCECDJ-1 →+0.113+1.598.037.04032
Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Exploration