Across TCGA cell cohorts, TTLL3 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible TTLL3-associated genes across cancer lineages are CCL18, PGK2, and OR6C1. Each is linked with TTLL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTLL3-to-partner and partner-to-TTLL3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTLL3→partner) and Y-score (partner→TTLL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CCL18 →	+0.050	+4.212	<.001	.007	3	2
BLOOD_Lymphoma	PGK2 →	+0.037	+4.523	<.001	.004	3	1
BLOOD_Lymphoma	OR6C1 →	+0.010	+5.247	<.001	.001	3	1
BLOOD_Lymphoma	OR2M3 →	+0.029	+4.191	<.001	.007	3	1
SKIN	MT1B →	+0.095	+4.415	<.001	.007	3	1
BREAST	PRSS54 →	+0.059	+4.672	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Exploration

TTLL3 survival (RNA) · tumor vs normal (RNA) · all TTLL3 data types