TTLL2

Across TCGA patient cohorts, TTLL2 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTLL2-associated genes across cancer lineages are Ku80, MYH11, and 4E-BP1. Each is linked with TTLL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TTLL2-to-partner and partner-to-TTLL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by TTLL2-low versus TTLL2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTLL2→partner) and Y-score (partner→TTLL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Ku80 →	+0.285	+2.841	.038	.035	3	3
SKCM	MYH11 →	-0.854	-2.700	.026	.006	3	3
UCEC	4E-BP1 →	+0.302	+3.584	.001	.002	3	3
SKCM	Lck →	-0.347	-2.321	.020	.033	3	2
SKCM	MSH2 →	+0.223	+2.017	.024	.018	3	2
SKCM	YAP_pS127 →	-0.332	-3.000	.038	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Ku80 by TTLL2 expression — LUAD

Explore this box plot interactively →