TTLL2

Across TCGA cell cohorts, TTLL2 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,490 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible TTLL2-associated GO terms across cancer lineages are Regulation of myoblast fusion, Immune response-activating cell surface receptor signaling pathway, and Nucleoside triphosphate metabolic process. Each is linked with TTLL2 in more than 6 cancer types. Because this analysis shows association rather than direction, both TTLL2-to-partner and partner-to-TTLL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of myoblast fusion grouped by TTLL2-low versus TTLL2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TTLL2→partner) and Y-score (partner→TTLL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of myoblast fusion →	+0.082	+0.334	<.001	.001	3	6
BONE	Immune response-activating cell surface receptor signaling pathway →	-0.044	-0.134	<.001	<.001	3	6
BONE	Nucleoside triphosphate metabolic process →	+0.071	+0.127	.005	.001	3	6
LUNG_NSCLC_LUAD	Positive regulation of translation →	+0.032	+0.119	.001	.006	2	7
LUNG_SCLC	Regulation of protein localization to Cajal body →	+0.044	+0.489	.001	<.001	3	5
LUNG_SCLC	Positive regulation of protein localization to Cajal body →	+0.044	+0.489	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,490 associations by consensus.

Regulation of myoblast fusion by TTLL2 expression — LUNG_SCLC

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