TTLL2

Across TCGA cell cohorts, TTLL2 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TTLL2-associated genes across cancer lineages are MS4A6E, TEKT1, and KRTAP11-1. Each is linked with TTLL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTLL2-to-partner and partner-to-TTLL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MS4A6E grouped by TTLL2-low versus TTLL2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTLL2→partner) and Y-score (partner→TTLL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MS4A6E →	+0.030	+4.415	.005	.007	3	1
SKIN	TEKT1 →	+0.057	+4.930	.005	.001	3	1
SKIN	KRTAP11-1 →	+0.019	+4.415	<.001	.007	3	1
SKIN	SCYGR10 →	+0.229	+4.684	<.001	.002	3	1
CNS	PRAMEF10 →	+0.221	+4.169	<.001	.008	3	1
CNS	FAM25G →	+0.542	+3.643	.009	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

MS4A6E by TTLL2 expression — SKIN

Explore this box plot interactively →