TTLL1

Across TCGA patient cohorts, TTLL1 mutation is significantly associated with the RNA expression of many other genes, with 1,079 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTLL1-associated genes across cancer lineages are RNU6-99P, RNA5SP97, and RNU6-130P. Each is linked with TTLL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTLL1-to-partner and partner-to-TTLL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-99P grouped by TTLL1-low versus TTLL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTLL1→partner) and Y-score (partner→TTLL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-99P →	+0.094	+3.890	<.001	.007	3	2
UCEC	RNA5SP97 →	+0.328	+1.847	.005	.009	3	2
COAD	RNU6-130P →	+0.930	+3.758	.004	.006	3	2
UCEC	TCP11X3P →	+0.196	+1.895	.004	.003	3	2
UCEC	RNA5SP461 →	+0.178	+3.890	<.001	.007	3	2
UCEC	INSL4 →	+0.918	+2.454	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,079 associations by consensus.

RNU6-99P by TTLL1 expression — UCEC

Explore this box plot interactively →