TTLL1

Across TCGA patient cohorts, TTLL1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTLL1-associated genes across cancer lineages are ATM, EGFR_pY1068, and Acetyl-a-Tubulin-Lys40. Each is linked with TTLL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTLL1-to-partner and partner-to-TTLL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TTLL1-low versus TTLL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTLL1→partner) and Y-score (partner→TTLL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.610	-2.321	.002	.034	3	2
UCEC	EGFR_pY1068 →	-0.324	-2.321	.003	.033	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.497	+3.179	.025	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.197	-3.000	.007	.036	3	1
UCEC	JNK2 →	+0.300	+3.331	<.001	.005	3	1
UCEC	MEK1 →	+0.348	+2.459	.029	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

ATM by TTLL1 expression — UCEC

Explore this box plot interactively →