TTLL1

Across TCGA cell cohorts, TTLL1 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TTLL1-associated genes across cancer lineages are CLEC9A and DEFA4. Each is linked with TTLL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTLL1-to-partner and partner-to-TTLL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLEC9A grouped by TTLL1-low versus TTLL1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTLL1→partner) and Y-score (partner→TTLL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CLEC9A →	+0.012	+4.977	<.001	.007	3	1
LUNG_NSCLC_LUAD	DEFA4 →	+0.032	+5.662	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

CLEC9A by TTLL1 expression — LARGE_INTESTINE

Explore this box plot interactively →