TTF2

Across TCGA pan-cancer cohorts, TTF2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TTF2 data layer compared with 21 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher TTF2 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TTF2 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

LSCC, HNSC, and CCRCC are the cancer types where TTF2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	II,III,IV	0.884	0.438	.001	37	view →
HNSC	DFS	Quartile	III,IV	0.554	0.882	.005	18	view →
CCRCC	OS	Quartile	II,III,IV	0.877	0.477	.005	13	view →
GBM	DFS	Tertile	All	0.241	0.490	.006	10	view →
UCEC	DFS	Median	All	0.779	0.929	.012	8	view →
PDAC	DFS	Quartile	All	0.603	0.312	.023	8	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TTF2–LSCC (OS)

Open the LSCC breakdown →