TTF2

Across TCGA patient cohorts, TTF2 mutation is significantly associated with the RNA expression of many other genes, with 4,034 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTF2-associated genes across cancer lineages are OGFRP1, IFRD2, and RANGAP1. Each is linked with TTF2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TTF2-to-partner and partner-to-TTF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OGFRP1 grouped by TTF2-low versus TTF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTF2→partner) and Y-score (partner→TTF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OGFRP1 →	+0.296	+1.769	.001	.003	3	3
UCEC	IFRD2 →	+0.483	+3.130	<.001	<.001	3	3
UCEC	RANGAP1 →	+0.459	+2.343	<.001	<.001	3	3
UCEC	PSMD9 →	+0.385	+2.000	<.001	.001	3	3
UCEC	OGFOD2 →	+0.254	+2.543	<.001	<.001	3	3
UCEC	MTFR2 →	+0.465	+2.095	.008	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,034 associations by consensus.

OGFRP1 by TTF2 expression — UCEC

Explore this box plot interactively →