TTF2

Across TCGA patient cohorts, TTF2 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTF2-associated genes across cancer lineages are JNK_pT183_Y185, Acetyl-a-Tubulin-Lys40, and Notch1. Each is linked with TTF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTF2-to-partner and partner-to-TTF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by TTF2-low versus TTF2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTF2→partner) and Y-score (partner→TTF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	JNK_pT183_Y185 →	-0.172	-3.169	.048	.018	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.389	+1.662	.030	.011	3	2
UCEC	Notch1 →	+0.136	+1.710	.006	.025	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.365	-1.349	.021	.037	3	2
UCEC	Shc_pY317 →	-0.153	-1.584	.004	.034	3	2
BLCA	Chk2_pT68 →	+0.212	+3.321	.003	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

JNK_pT183_Y185 by TTF2 expression — BLCA

Explore this box plot interactively →