TTF2

Across TCGA cell cohorts, TTF2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,000 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TTF2-associated GO terms across cancer lineages are Termination of RNA polymerase II transcription, DNA replication, and DNA-templated DNA replication. Each is linked with TTF2 in more than 17 cancer types. Because this analysis shows association rather than direction, both TTF2-to-partner and partner-to-TTF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Termination of RNA polymerase II transcription grouped by TTF2-low versus TTF2-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TTF2→partner) and Y-score (partner→TTF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Termination of RNA polymerase II transcription →	+0.133	+1.065	<.001	<.001	3	18
BONE	DNA replication →	+0.114	+1.101	.002	.005	3	17
BLOOD_Myeloma	DNA-templated DNA replication →	+0.132	+1.433	<.001	<.001	3	17
BONE	Double-strand break repair →	+0.090	+1.185	<.001	.001	3	17
UPPER_AERODIGESTIVE_TRACT	Centrosome cycle →	+0.090	+1.097	<.001	<.001	3	17
BONE	Centriole replication →	+0.147	+1.513	.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,000 associations by consensus.

Termination of RNA polymerase II transcription by TTF2 expression — LIVER

Explore this box plot interactively →