TTF2

Across TCGA cell cohorts, TTF2 mutation is significantly associated with the RNA expression of many other genes, with 1,688 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TTF2-associated genes across cancer lineages are OR4M2, C20orf85, and OR1L4. Each is linked with TTF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTF2-to-partner and partner-to-TTF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4M2 grouped by TTF2-low versus TTF2-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTF2→partner) and Y-score (partner→TTF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR4M2 →	+0.130	+4.930	<.001	.008	3	2
SOFT_TISSUE	C20orf85 →	+0.115	+5.369	<.001	.004	3	1
SOFT_TISSUE	OR1L4 →	+0.072	+5.369	<.001	.004	3	1
SOFT_TISSUE	OR4D6 →	+0.046	+5.977	<.001	.001	3	1
SOFT_TISSUE	OR51L1 →	+0.036	+5.369	<.001	.004	3	1
SOFT_TISSUE	OR51G2 →	+0.036	+5.369	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,688 associations by consensus.

OR4M2 by TTF2 expression — SOFT_TISSUE

Explore this box plot interactively →