TTF1

Across TCGA pan-cancer cohorts, TTF1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TTF1 data layer compared with 21 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher TTF1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TTF1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

LSCC, CCRCC, and GBM are the cancer types where TTF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.896	0.370	<.001	31	view →
CCRCC	DFS	Tertile	All	1.000	0.439	.003	21	view →
GBM	DFS	Tertile	All	0.186	0.477	.001	16	view →
HNSC	OS	Median	All	0.484	1.000	.038	6	view →
PDAC	OS	Median	All	0.682	0.418	.041	4	view →
UCEC	OS	Quartile	All	1.000	0.875	.043	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TTF1–LSCC (DFS)

Open the LSCC breakdown →