TTF1

Across TCGA patient cohorts, TTF1 protein abundance is significantly associated with the RNA expression of many other genes, with 10,581 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TTF1-associated genes across cancer lineages are FAM72A, FAM72D, and CDK2. Each is linked with TTF1 in more than 3 cancer types. Because this analysis shows association rather than direction, both TTF1-to-partner and partner-to-TTF1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TTF1 versus FAM72A in OV, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTF1→partner) and Y-score (partner→TTF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FAM72A →	+0.726	+0.605	.001	<.001	3	4
BRCA	FAM72D →	+0.839	+0.358	<.001	<.001	3	4
LSCC	CDK2 →	+0.641	+0.486	<.001	<.001	3	3
OV	PXMP2 →	+0.502	+0.514	.001	.004	3	3
LSCC	RPSAP63 →	+0.533	+0.247	<.001	<.001	3	3
LSCC	ZNF706 →	+0.652	+0.367	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,581 associations by consensus.

TTF1 vs FAM72A — OV

Explore this scatter interactively →