TTF1

Across TCGA patient cohorts, TTF1 mutation is significantly associated with the RNA expression of many other genes, with 4,250 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTF1-associated genes across cancer lineages are MRPL18, PKM, and SMC3. Each is linked with TTF1 in more than 3 cancer types. Because this analysis shows association rather than direction, both TTF1-to-partner and partner-to-TTF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL18 grouped by TTF1-low versus TTF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTF1→partner) and Y-score (partner→TTF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPL18 →	+0.424	+2.513	<.001	<.001	3	4
UCEC	PKM →	+0.380	+1.999	.005	<.001	3	4
UCEC	SMC3 →	+0.463	+2.178	.005	.001	3	3
UCEC	TMEM33 →	+0.565	+1.765	<.001	<.001	3	3
UCEC	KRR1 →	+0.396	+2.161	<.001	<.001	3	3
UCEC	SLCO1B3 →	+0.717	+1.765	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,250 associations by consensus.

MRPL18 by TTF1 expression — UCEC

Explore this box plot interactively →