TTF1

Across TCGA patient cohorts, TTF1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTF1-associated genes across cancer lineages are VHL, MEK1, and Cyclin-B1. Each is linked with TTF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TTF1-to-partner and partner-to-TTF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by TTF1-low versus TTF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTF1→partner) and Y-score (partner→TTF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.623	-1.362	.005	.034	3	3
UCEC	MEK1 →	+0.380	+2.584	.001	.001	3	2
SKCM	Cyclin-B1 →	+0.464	+3.321	.028	.010	2	3
UCEC	JNK2 →	+0.201	+1.834	.002	.013	3	2
UCEC	Annexin-1 →	+0.396	+1.874	.022	.049	3	2
UCEC	S6_pS240_S244 →	+0.317	+1.807	.018	.025	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

VHL by TTF1 expression — UCEC

Explore this box plot interactively →