TTF1

Across TCGA cell cohorts, TTF1 mutation is significantly associated with the RNA expression of many other genes, with 490 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TTF1-associated genes across cancer lineages are ARHGEF10, PTCH2, and NUP43. Each is linked with TTF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTF1-to-partner and partner-to-TTF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARHGEF10 grouped by TTF1-low versus TTF1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTF1→partner) and Y-score (partner→TTF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ARHGEF10 →	+1.186	+2.459	.001	.006	3	2
LARGE_INTESTINE	PTCH2 →	+0.303	+3.459	<.001	<.001	3	2
LARGE_INTESTINE	NUP43 →	+0.412	+1.949	.007	.002	3	2
LARGE_INTESTINE	LRRC39 →	+0.485	+2.544	<.001	<.001	3	2
LARGE_INTESTINE	RSAD1 →	+0.654	+2.584	.001	.001	3	2
LARGE_INTESTINE	SNX27 →	+0.443	+2.700	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 490 associations by consensus.

ARHGEF10 by TTF1 expression — LARGE_INTESTINE

Explore this box plot interactively →