TTF1

Across TCGA cell cohorts, TTF1 mutation is significantly associated with the mutation status of many other genes, with 3,469 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TTF1-associated genes across cancer lineages are USH2A, PIK3C2A, and NAV1. Each is linked with TTF1 in more than 4 cancer types. Because this analysis shows association rather than direction, both TTF1-to-partner and partner-to-TTF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USH2A grouped by TTF1-low versus TTF1-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTF1→partner) and Y-score (partner→TTF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	USH2A →	+4.139	+4.786	.001	.001	1	5
BLOOD_Lymphoma	PIK3C2A →	+3.969	+3.969	.002	.002	1	5
LARGE_INTESTINE	NAV1 →	+1.617	+1.739	.002	.002	1	5
BLOOD_Lymphoma	ZNF318 →	+3.969	+3.969	.002	.002	1	5
LUNG_NSCLC_LUSC	KDM3B →	+4.228	+4.228	.004	.004	1	4
PANCREAS	EP300 →	+2.707	+3.353	.004	.004	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,469 associations by consensus.

USH2A by TTF1 expression — KIDNEY

Explore this box plot interactively →