TTC9

Across TCGA pan-cancer cohorts, TTC9 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TTC9 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TTC9 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TTC9 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

LUAD, CCRCC, and HNSC are the cancer types where TTC9 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.624	0.858	.002	18	view →
CCRCC	DFS	Quartile	III,IV	0.723	0.405	.027	10	view →
HNSC	DFS	Quartile	All	0.889	0.646	.008	8	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TTC9–LUAD (DFS)

Open the LUAD breakdown →