TTC9

Across TCGA cell cohorts, TTC9 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,794 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TTC9-associated GO terms across cancer lineages are Membrane biogenesis, Negative regulation of Arp2/3 complex-mediated actin nucleation, and Keratinocyte development. Each is linked with TTC9 in more than 10 cancer types. Because this analysis shows association rather than direction, both TTC9-to-partner and partner-to-TTC9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Membrane biogenesis grouped by TTC9-low versus TTC9-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC9→partner) and Y-score (partner→TTC9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Membrane biogenesis →	+0.115	+1.888	<.001	<.001	3	11
OVARY	Negative regulation of Arp2/3 complex-mediated actin nucleation →	+0.149	+1.253	.009	.003	3	11
LUNG_NSCLC_LUAD	Keratinocyte development →	-0.474	-1.895	<.001	<.001	3	11
OVARY	Negative regulation of tumor necrosis factor production →	+0.092	+1.093	<.001	.001	3	10
URINARY_TRACT	Response to indole-3-methanol →	+0.195	+1.846	<.001	<.001	3	10
STOMACH	Small GTPase-mediated signal transduction →	+0.056	+1.820	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,794 associations by consensus.

Membrane biogenesis by TTC9 expression — PANCREAS

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