TTC7A

Across TCGA pan-cancer cohorts, TTC7A mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated TTC7A data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher TTC7A mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TTC7A expression acts as an unfavorable survival marker, although some lineages such as CCRCC and UCEC show a favorable association.

CCRCC, UCEC, and GBM are the cancer types where TTC7A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	All	0.966	0.293	.008	15	view →
UCEC	OS	Median	II,III,IV	1.000	0.634	.015	8	view →
GBM	OS	Median	All	0.773	0.935	.017	3	view →
PDAC	DFS	Tertile	III,IV	0.868	0.459	.047	2	view →
LUAD	OS	Tertile	III,IV	0.816	0.319	.040	2	view →
HNSC	DFS	Quartile	IV	0.894	1.000	.041	1	view →
LSCC	DFS	Tertile	All	0.587	0.916	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

TTC7A–CCRCC (OS)

Open the CCRCC breakdown →