TTC6

Across TCGA pan-cancer cohorts, TTC6 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TTC6 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher TTC6 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TTC6 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

THYM, UCEC, and KIRP are the cancer types where TTC6 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
UCEC	DFS	Median	II,III,IV	1.000	0.301	.003	36	view →
KIRP	OS	Median	All	0.161	0.904	<.001	27	view →
COAD	OS	Median	All	0.168	0.806	.002	12	view →
LUAD	OS	Median	II,III,IV	0.090	0.709	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TTC6–THYM (OS)

Open the THYM breakdown →