TTC6

Across TCGA cell cohorts, TTC6 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,046 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible TTC6-associated GO terms across cancer lineages are Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, Negative regulation of biomineral tissue development, and Chromosomal 5-methylcytosine DNA demethylation pathway. Each is linked with TTC6 in more than 7 cancer types. Because this analysis shows association rather than direction, both TTC6-to-partner and partner-to-TTC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay grouped by TTC6-low versus TTC6-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC6→partner) and Y-score (partner→TTC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay →	+0.133	+1.575	<.001	<.001	3	8
OESOPHAGUS	Negative regulation of biomineral tissue development →	-0.132	-1.672	<.001	<.001	3	7
LARGE_INTESTINE	Chromosomal 5-methylcytosine DNA demethylation pathway →	+0.155	+0.726	<.001	<.001	3	7
LUNG_SCLC	Regulation of collagen biosynthetic process →	-0.100	-1.340	<.001	<.001	3	7
LUNG_SCLC	Regulation of alternative mRNA splicing, via spliceosome →	+0.084	+1.690	<.001	<.001	2	8
BREAST	Nuclear body organization →	-0.116	-2.077	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,046 associations by consensus.

Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay by TTC6 expression — LUNG_SCLC

Explore this box plot interactively →